Application of Factorial Design Method for the Optimization of Reaction Conditions Influencing Viscosity of Poly(amide-imide-ether-urethane)s Based PEG and L-leucine

For the first time, we report the optimization of reaction conditions for the synthesis of novel thermally modified optically active pol (amide-imide-ether-urethane)s (PAIEU)s prepared by diisocyanate route. The effects and importance of different reaction parameters such as reaction temperature, reaction time, and soft segment length on the controlling of chain growth of the resulting copolymers were investigated.