فعالیت‌های پژوهشی

Journal Paper Synthesis and Characterization of a New Cu (BHB)2/Fe-MIL-101-NH2 Composite: A Novel Hydrogen Peroxide Sensor based upon the Bimetallic Complex

Hydrogen peroxide (H2O2) serves a significant role in biological tissues. Throughout this manuscript, the synthesis of a copper complex on the Fe-MIL-101-NH2 surface functionalized with 5-bromo-2-hydroxy-benzaldehyde (BHB), Cu(BHB)2/Fe-MIL-101-NH2 composite was characterized by various techniques. The glassy carbon electrode (GCE) was modified with the Cu (BHB)2/Fe-MIL-101-NH2 heterostructure to prepare Cu (BHB)2/Fe-MIL-101-NH2/GCE and used for the electrochemical detection of H2O2.

Potent cyclometallated Pd(ii) antitumor complexes bearing α-amino acids: synthesis, structural characterization, DNA/BSA binding, cytotoxicity and molecular dynamics simulation

A rational approach was adopted to design high-potential metal-based antitumor agents. A series of organometallic Pd(II) complexes with a general formula of [Pd{κ2 (C,C)-[(C6H4-2)PPh2]CH(CO)C6H4Ph-4} {κ2 (N,O)}] (N,O = alanine (Pd-A), valine (Pd-V), leucine (Pd-L), L-isoleucine (Pd-I) and phenylalanine (PdF)) were prepared by cyclopalladation of the phosphorus ylide, bridge cleavage reaction and subsequent chelation of natural α-amino acids. The complexes were fully identified using IR and multinuclear 1 H, 13C, 31P NMR spectroscopic methods.

Synthesis, spectroscopic characterization and in vitro cytotoxicities of new organometallic palladium complexes with biologically active β-diketones; Biological evaluation probing of the interaction mechanism with DNA/Protein and molecular docking

[Pd{(C,N)-C6H4CH (CH3)NH}(CUR)] (3) and [Pd2{(C,N)-C6H4CH(CH3)NH2}2(µ-N3CS2)] 17 (4) [cur =1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dion] novel 18 organometallic complexes with biologically active ligands have been prepared and characterized via elemental analysis, multinuclear spectroscopic techniques (1H, and 13 19 C 20 NMR and IR) and their biological activities, including antitumoral activity and DNA-protein 21 interactions have been investigated.

Design and synthesis of a novel trinuclear palladium (ii) complex containing an oxime chelate ligand: Determining the interaction mechanism with the DNA groove and BSA site I …

The novel trinuclear Pd(II) complex with an aryl oxime ligand, [Pd3(C,N-(C6H4C(Cl)NO)-4)6], was synthesized and structurally characterized by elemental analysis (C, H, N), IR, resonance signals in the NMR, and single crystal X-ray crystallography. The interaction ability of the complex with native calf thymus DNA (CT-DNA) was monitored as a function of the metal complex–DNA molar ratio by UV-Vis absorption spectrophotometry, fluorescence spectroscopy, circular dichroism (CD) and thermal denaturation methods.