(A) (A)tA molecular docking perspective of trans-[Cu(Pir)2(THF)2] with the major groove of DNA using UCSF Chimera. The complex is depicted in a stick model, and DNA is represented in a wireframe model; (B) two-dimensional interactions generated byLIGPLOT+

Treatment of K562 cells with the various oxicam complexes and the oxicam ligands showed different inhibition effects in a concentration dependent manner. The cell inhibition was measured after 48 h by the MTT assay.

Treatment of K562 cells with the various oxicam complexes and the oxicam ligands showed different inhibition effects in a concentration dependent manner. The cell inhibition was measured after 48 h by the MTT assay. Each data point represents the mean for three separate experiments.

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DNA- ligand binding pose in major groove of mixed sequence (PDB ID: 423D) (A), in minor groove of DNA crystal structures GC rich (PDB ID: 1QC1) (B), and AT rich (PDB ID: 226D) (C); The hydrogen bonding interaction between DNA and 4-OHPh-tpy, mixed sequenc